En 2022, 
Trabzonspor goleó 4–0 a 
AS Monaco en Fase de grupos de UEFA Europa League.
Partidos de Southampton
Southampton
Final
Sunderland AFC
3–0
Sunderland AFC
Coventry City
Final
Southampton
1–1
Southampton
Southampton
Final
Middlesbrough
4–0
Middlesbrough
Wimbledon FC
Final
Southampton
3–1
Southampton
Southampton
Final
Tottenham Hotspur
0–1
Tottenham Hotspur
Liverpool FC
Final
Southampton
2–1
Southampton
Southampton
Final
Nottingham Forest
2–2
Nottingham Forest
West Ham United
Final
Southampton
2–1
Southampton
Leicester City
Final
Southampton
2–1
Southampton
Southampton
Final
Chelsea FC
0–0
Chelsea FC
Southampton
Final
Wimbledon FC
0–0
Wimbledon FC
Bolton Wanderers
Final
Southampton
0–1
Southampton
Newcastle United
Final
Southampton
1–0
Southampton
Southampton
Final
Manchester United
3–1
Manchester United
Aston Villa
Final
Southampton
3–0
Southampton
Southampton
Final
Blackburn Rovers
1–0
Blackburn Rovers
Leeds United
Final
Southampton
1–0
Southampton
Queens Park Rangers
Final
Southampton
3–0
Southampton
Southampton
Final
Coventry City
1–0
Coventry City
Southampton
Final
Sheffield Wednesday
0–1
Sheffield Wednesday
Manchester City
Final
Southampton
2–1
Southampton
Tottenham Hotspur
Final
Southampton
1–0
Southampton
Southampton
Final
Chelsea FC
2–3
Chelsea FC
Southampton
Final
Everton FC
2–2
Everton FC
Southampton
Final
Manchester City
1–1
Manchester City
Southampton
Final
Middlesbrough
2–1
Middlesbrough
Nottingham Forest
Final
Southampton
1–0
Southampton
Coventry City
Final
Southampton
1–1
Southampton
Southampton
Final
Tottenham Hotspur
0–0
Tottenham Hotspur
Sheffield Wednesday
Final
Southampton
2–2
Southampton
West Ham United
Final
Southampton
2–1
Southampton
Southampton
Final
Arsenal FC
0–0
Arsenal FC
Liverpool FC
Final
Southampton
1–1
Southampton
Southampton
Final
Bolton Wanderers
1–0
Bolton Wanderers
Southampton
Final
Aston Villa
0–1
Aston Villa
Manchester United
Final
Southampton
4–1
Southampton
Southampton
Final
Queens Park Rangers
2–0
Queens Park Rangers
Wimbledon FC
Final
Southampton
1–2
Southampton
Southampton
Final
Liverpool FC
1–3
Liverpool FC
Blackburn Rovers
Final
Southampton
2–1
Southampton
Southampton
Final
West Ham United
0–0
West Ham United
Arsenal FC
Final
Southampton
4–2
Southampton
Chelsea FC
Final
Southampton
3–0
Southampton
Middlesbrough
Final
Southampton
0–0
Southampton
Southampton
Final
Newcastle United
1–0
Newcastle United
Southampton
Final
Leeds United
1–1
Leeds United
Everton FC
Final
Southampton
2–0
Southampton
Southampton
Final
Nottingham Forest
3–4
Nottingham Forest
Southampton
Final
Leicester City
2–2
Leicester City
Manchester United
Final
Southampton
2–1
Southampton
Everton FC
Final
Southampton
0–0
Southampton
Southampton
Final
Crystal Palace
3–1
Crystal Palace
Southampton
Final
Sheffield Wednesday
0–0
Sheffield Wednesday
Wimbledon FC
Final
Southampton
0–2
Southampton
Southampton
Final
Queens Park Rangers
2–1
Queens Park Rangers
Chelsea FC
Final
Southampton
0–2
Southampton
Liverpool FC
Final
Southampton
3–1
Southampton
Southampton
Final
Tottenham Hotspur
4–3
Tottenham Hotspur
Southampton
Final
Newcastle United
3–1
Newcastle United
Nottingham Forest
Final
Southampton
3–0
Southampton
Southampton
Final
West Ham United
1–1
West Ham United
Southampton
Final
Coventry City
0–0
Coventry City
Ipswich Town
Final
Southampton
2–1
Southampton
Norwich City
Final
Southampton
2–2
Southampton
Southampton
Final
Manchester City
2–2
Manchester City
Arsenal FC
Final
Southampton
1–1
Southampton
Leeds United
Final
Southampton
0–0
Southampton
Sheffield Wednesday
Final
Southampton
1–1
Southampton
Southampton
Final
Manchester United
2–2
Manchester United
Queens Park Rangers
Final
Southampton
2–2
Southampton
Southampton
Final
Wimbledon FC
2–3
Wimbledon FC
Southampton
Final
Aston Villa
2–1
Aston Villa
Blackburn Rovers
Final
Southampton
3–2
Southampton
Southampton
Final
Chelsea FC
0–1
Chelsea FC
Crystal Palace
Final
Southampton
0–0
Southampton
Southampton
Final
Arsenal FC
1–0
Arsenal FC
Manchester City
Final
Southampton
3–3
Southampton
Southampton
Final
Norwich City
1–1
Norwich City
Southampton
Final
Leeds United
1–3
Leeds United
West Ham United
Final
Southampton
2–0
Southampton
Leicester City
Final
Southampton
4–3
Southampton
Southampton
Final
Everton FC
2–0
Everton FC
Southampton
Final
Ipswich Town
3–1
Ipswich Town
Coventry City
Final
Southampton
1–3
Southampton
Southampton
Final
Nottingham Forest
1–1
Nottingham Forest
Tottenham Hotspur
Final
Southampton
1–2
Southampton
Southampton
Final
Liverpool FC
0–2
Liverpool FC
Newcastle United
Final
Southampton
5–1
Southampton
Aston Villa
Final
Southampton
1–1
Southampton
Southampton
Final
Blackburn Rovers
1–1
Blackburn Rovers
West Ham United
Final
Southampton
3–3
Southampton
Manchester United
Final
Southampton
2–0
Southampton
Southampton
Final
Aston Villa
4–1
Aston Villa
Tottenham Hotspur
Final
Southampton
3–0
Southampton
Southampton
Final
Blackburn Rovers
3–1
Blackburn Rovers
Norwich City
Final
Southampton
4–5
Southampton
Southampton
Final
Manchester City
0–1
Manchester City
Chelsea FC
Final
Southampton
2–0
Southampton
Southampton
Final
Oldham Athletic
1–3
Oldham Athletic
Sheffield United
Final
Southampton
0–0
Southampton
En 2017, 
Cañuelas goleó 4–0 a 
Defensores de Cambaceres en Fecha 8 de Primera C.
En 2022, 
SC Freiburg goleó 4–0 a Nantes en Fase de grupos de UEFA Europa League.
En 2022, PSV goleó 5–0 a Zürich en Fase de grupos de UEFA Europa League.
↗En 2022, Silkeborg IF goleó 5–0 a 
FCSB en Fase de grupos de UEFA Conference League.