En 2022, PSV goleó 5–0 a Zürich en Fase de grupos de UEFA Europa League.
↗Partidos de Sampdoria
Sampdoria
Final
Parma
1–0
Parma
US Palermo
UP
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Cagliari Calcio
0–0
Cagliari Calcio
Atalanta BC
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
AC Milan
0–1
AC Milan
Chievo Verona
CV
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
BC
Brescia Calcio
0–1
Reggina Calcio
RC
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
AL
As Livorno
2–0
ACF Fiorentina
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
Juventus
0–3
Juventus
AC Siena
AS
Final
Sampdoria
2–1
Sampdoria
Sampdoria
Final
Lazio
0–1
Lazio
Sampdoria
Final
AS Roma
0–0
AS Roma
Juventus
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Udinese Calcio
1–3
Udinese Calcio
Modena FC
MF
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
APC
Ac Perugia Calcio
3–2
AC Siena
AS
Final
Sampdoria
0–0
Sampdoria
Ancona Calcio
AC
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
US Lecce
2–2
US Lecce
Empoli
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
Bologna
3–2
Bologna
AC Milan
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
CV
Chievo Verona
1–0
Sampdoria
Final
Parma
1–2
Parma
Brescia Calcio
BC
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
Inter Milan
2–2
Inter Milan
Lazio
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
RC
Reggina Calcio
2–0
AS Roma
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
Juventus
1–2
Juventus
Udinese Calcio
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
MF
Modena FC
1–1
Ac Perugia Calcio
APC
Final
Sampdoria
3–3
Sampdoria
Sampdoria
Final
AS
AC Siena
2–1
Sampdoria
Final
AC
Ancona Calcio
2–0
US Lecce
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
Empoli
2–0
Empoli
Bologna
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
AC Milan
0–3
AC Milan
Chievo Verona
CV
Final
Sampdoria
1–1
Sampdoria
Parma
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
BC
Brescia Calcio
2–1
Inter Milan
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
Lazio
1–2
Lazio
Reggina Calcio
RC
Final
Sampdoria
2–2
Sampdoria
Sampdoria
Final
AB
As Bari
1–0
Bologna
Final
Sampdoria
2–2
Sampdoria
Sampdoria
Final
ACF Fiorentina
3–2
ACF Fiorentina
AC Milan
Final
Sampdoria
3–2
Sampdoria
Sampdoria
Final
Lazio
0–1
Lazio
Parma
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
FUV
Fbc Unione Venezia
2–1
Vicenza Calcio
VC
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
Inter Milan
4–0
Inter Milan
Salernitana
S
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Juventus
1–2
Juventus
Empoli
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
PC
Piacenza Calcio
3–2
AS Roma
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
Cagliari Calcio
0–0
Cagliari Calcio
Ac Perugia Calcio
APC
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Udinese Calcio
1–1
Udinese Calcio
As Bari
AB
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
Bologna
1–1
Bologna
ACF Fiorentina
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
AC Milan
2–2
AC Milan
Lazio
Final
Sampdoria
5–2
Sampdoria
Sampdoria
Final
Parma
0–2
Parma
Fbc Unione Venezia
FUV
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
VC
Vicenza Calcio
0–0
Inter Milan
Final
Sampdoria
3–0
Sampdoria
Sampdoria
Final
S
Salernitana
1–0
Juventus
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Empoli
3–0
Empoli
Piacenza Calcio
PC
Final
Sampdoria
4–1
Sampdoria
Sampdoria
Final
AS Roma
2–1
AS Roma
Cagliari Calcio
Final
Sampdoria
5–0
Sampdoria
Sampdoria
Final
APC
Ac Perugia Calcio
1–1
Udinese Calcio
Final
Sampdoria
2–2
Sampdoria
AS Roma
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
US Lecce
1–1
US Lecce
Parma
Final
Sampdoria
2–2
Sampdoria
Sampdoria
Final
ACF Fiorentina
2–0
ACF Fiorentina
SSC Napoli
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
Empoli
3–0
Empoli
Inter Milan
Final
Sampdoria
3–0
Sampdoria
Sampdoria
Final
Bologna
2–3
Bologna
As Bari
AB
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
Lazio
0–4
Lazio
AC Milan
Final
Sampdoria
1–0
Sampdoria
Piacenza Calcio
PC
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
Udinese Calcio
0–3
Udinese Calcio
Juventus
Final
Sampdoria
3–0
Sampdoria
Sampdoria
Final
Atalanta BC
2–0
Atalanta BC
Sampdoria
Final
BC
Brescia Calcio
2–1
Vicenza Calcio
VC
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
AS Roma
1–1
AS Roma
US Lecce
Final
Sampdoria
1–3
Sampdoria
En 2022, ACF Fiorentina goleó 5–1 a 
Heart of Midlothian FC en Fase de grupos de UEFA Conference League.
En 2017, 
Cañuelas goleó 4–0 a 
Defensores de Cambaceres en Fecha 8 de Primera C.
En 2022, 
SC Freiburg goleó 4–0 a Nantes en Fase de grupos de UEFA Europa League.
En 2022, Silkeborg IF goleó 5–0 a 
FCSB en Fase de grupos de UEFA Conference League.