En 2022, 
Trabzonspor goleó 4–0 a 
AS Monaco en Fase de grupos de UEFA Europa League.
Partidos de Sampdoria
Metalist Kharkov
MK
Final
Global 3 – 0
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Global 0 – 3
MK
Metalist Kharkov
0–1
Sampdoria
Final
Sevilla
1–0
Sevilla
Standard Liège
SL
Final
Sampdoria
3–0
Sampdoria
Sampdoria
Final
VfB Stuttgart
1–1
VfB Stuttgart
Partizan
Final
Sampdoria
1–2
Sampdoria
Fbk Kaunas
FK
Final
Sampdoria
1–2
Sampdoria
Sampdoria
Final
FK
Fbk Kaunas
5–0
AaB
A
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
A
AaB
2–2
Sampdoria
Final
HS
Hajduk Split
1–1
Hajduk Split
HS
Final
Sampdoria
0–1
Sampdoria
ACF Fiorentina
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
AS
AC Siena
4–1
Atalanta BC
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
Udinese Calcio
3–1
Udinese Calcio
Calcio Catania
CC
Final
Sampdoria
1–2
Sampdoria
US Palermo
UP
Final
Sampdoria
2–2
Sampdoria
Sampdoria
Final
Udinese Calcio
2–2
Udinese Calcio
ACF Fiorentina
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
RC
Reggina Calcio
DERBY DELLA LANTERNA
5–0
Genoa CFC
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
Cagliari Calcio
3–3
Cagliari Calcio
Calcio Catania
CC
Final
Sampdoria
2–0
Sampdoria
US Lecce
Final
Sampdoria
1–3
Sampdoria
Sampdoria
Final
SSC Napoli
2–2
SSC Napoli
Torino FC
Final
Sampdoria
1–3
Sampdoria
Sampdoria
Final
AS Roma
2–2
AS Roma
Bologna
Final
Sampdoria
3–0
Sampdoria
Sampdoria
Final
AC Milan
2–1
AC Milan
Sampdoria
Final
Atalanta BC
1–0
Atalanta BC
Juventus
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
AS
AC Siena
2–2
Chievo Verona
CV
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
Lazio
3–1
Lazio
Inter Milan
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
UP
US Palermo
0–2
AS Roma
Final
Sampdoria
2–0
Sampdoria
Udinese Calcio
Final
Sampdoria
1–1
Sampdoria
Sampdoria
Final
ACF Fiorentina
0–1
ACF Fiorentina
Reggina Calcio
RC
Final
Sampdoria
DERBY DELLA LANTERNA
0–2
Sampdoria
Sampdoria
Final
Genoa CFC
0–1
Genoa CFC
Cagliari Calcio
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
CC
Calcio Catania
3–0
Sampdoria
Final
US Lecce
3–2
US Lecce
SSC Napoli
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Torino FC
1–0
Torino FC
Sampdoria
Final
Bologna
2–0
Bologna
AC Milan
Final
Sampdoria
3–0
Sampdoria
Atalanta BC
Final
Sampdoria
4–2
Sampdoria
Sampdoria
Final
Juventus
0–0
Juventus
AC Siena
AS
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
CV
Chievo Verona
1–1
Lazio
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Inter Milan
1–1
Inter Milan
Sampdoria
Final
Juventus
3–3
Juventus
US Palermo
UP
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
AS Roma
0–3
AS Roma
ACF Fiorentina
Final
Sampdoria
2–2
Sampdoria
Sampdoria
Final
Udinese Calcio
3–0
Udinese Calcio
Reggina Calcio
RC
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
AL
As Livorno
2–0
Empoli
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
Cagliari Calcio
1–1
Cagliari Calcio
AC Milan
Final
Sampdoria
1–2
Sampdoria
Sampdoria
Final
CC
Calcio Catania
3–1
Parma
Final
Sampdoria
1–2
Sampdoria
Sampdoria
Final
Torino FC
2–2
Torino FC
Atalanta BC
Final
Sampdoria
4–1
Sampdoria
Sampdoria
Final
Inter Milan
DERBY DELLA LANTERNA
1–1
Inter Milan
Genoa CFC
Final
Sampdoria
0–1
Sampdoria
Sampdoria
Final
SSC Napoli
2–0
SSC Napoli
Lazio
Final
Sampdoria
2–1
Sampdoria
Sampdoria
Final
AS
AC Siena
1–0
Juventus
Final
Sampdoria
0–0
Sampdoria
Sampdoria
Final
UP
US Palermo
3–0
AS Roma
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
ACF Fiorentina
2–2
ACF Fiorentina
Udinese Calcio
Final
Sampdoria
3–2
Sampdoria
Sampdoria
Final
RC
Reggina Calcio
3–0
As Livorno
AL
Final
Sampdoria
3–1
Sampdoria
Sampdoria
Final
Empoli
3–0
Empoli
Cagliari Calcio
Final
Sampdoria
0–3
Sampdoria
Sampdoria
Final
AC Milan
0–5
AC Milan
Calcio Catania
CC
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Parma
3–0
Parma
Torino FC
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
Atalanta BC
3–0
Atalanta BC
Inter Milan
Final
Sampdoria
DERBY DELLA LANTERNA
3–0
Sampdoria
Sampdoria
Final
Genoa CFC
0–0
Genoa CFC
SSC Napoli
Final
Sampdoria
2–0
Sampdoria
Sampdoria
Final
Lazio
0–0
Lazio
AC Siena
AS
Final
Sampdoria
1–2
Sampdoria
ACF Fiorentina
Final
Sampdoria
5–1
Sampdoria
Sampdoria
Final
C
Catania
1–0
Livorno
L
Final
Sampdoria
1–0
Sampdoria
Sampdoria
Final
R
Reggina
0–0
Siena
S
Final
Sampdoria
0–2
Sampdoria
Sampdoria
Final
M
Messina
3–1
AS Roma
Final
Sampdoria
4–0
Sampdoria
En 2022, 
SC Freiburg goleó 4–0 a Nantes en Fase de grupos de UEFA Europa League.
En 2022, Silkeborg IF goleó 5–0 a 
FCSB en Fase de grupos de UEFA Conference League.
En 2022, PSV goleó 5–0 a Zürich en Fase de grupos de UEFA Europa League.
↗En 2022, ACF Fiorentina goleó 5–1 a 
Heart of Midlothian FC en Fase de grupos de UEFA Conference League.